I hadn't made a big-budget film and in Hollywood there's a sort of man and boys situation. You're a man you make $80 million movies! As if it's harder to make an $80 million movie. Well I guess businesswise it is because you have more executives to argue with.
If you talk to geneticists they are constantly finding that your genes are being switched on and off because of the environment. Genes alone do not determine an exact path in your life.