I don't think I could play a character that I couldn't relate to somehow. I'm not unfamiliar with frustration anger shame helplessness and a load of other emotions that make up our psycho-soup. I try to focus on that frustration that sense of unfairness and multiply it.
Well we can't say any more than we can say there is no god there is no afterlife. We can only say there is no persuasive evidence for or argument for it.