I start really missing London when I go away. I have a little flat but very central. I live above a pub and you'd think it'd be a nightmare but I like hearing the music and it's quite comforting.
One thing that being a scientist has taught me is that you can never be certain about anything. You never know the truth. You can only approach it and hope to get a bit nearer to it each time. You iterate towards the truth. You don't know it.