Thousands of years ago humans domesticated every possible large wild mammal species fulfilling all those criteria and worth domesticating with the result that there have been no valuable additions of domestic animals in recent times despite the efforts of modern science.

I very much enjoyed my career in science. I didn't leave science because I was disillusioned but felt I'd done my bit for it after about twenty-five years.

The world has changed - through technology through wine-making techniques the quality of wine is greater than it's ever been. Whereas ten fifteen years ago it was very easy to find lots of bad wine it's kind of hard now. The technology the science - it's like are you kidding? We're in the golden years of wine!

Economics has never been a science - and it is even less now than a few years ago.

This much we know: Journalism is not a precise science. It's on its best day is a crude art. We make mistakes I make mistakes. With more than 50 years as a journalist I have at least had the opportunity to blow more stories make more mistakes than maybe anybody in television.

The science linking the increased frequency and severity of extreme weather to the climate crisis has matured tremendously in the last couple of years.

Millions of people were inspired by the Apollo Program. I was five years old when I watched Apollo 11 unfold on television and without any doubt it was a big contributor to my passions for science engineering and exploration.

If you start any large theory such as quantum mechanics plate tectonics evolution it takes about 40 years for mainstream science to come around. Gaia has been going for only 30 years or so.

Science has done more for the development of western civilization in one hundred years than Christianity did in eighteen hundred years.

We are born at a given moment in a given place and like vintage years of wine we have the qualities of the year and of the season of which we are born. Astrology does not lay claim to anything more.

The last few years have been my happiest. I'm happy in the years that most people are blue and sad and waiting to die. I don't feel that a bit. Smiling has a lot to do with it. You can just lift your spirits by smiling a little bit.

'Eyes Wide Open' took shape from two real life events straight from my own past. One was the sad suicide of my young nephew a troubled kid who was found at the bottom of a landmark cliff in central California. The second was a chance encounter forty years ago with none other than ahem Charles Manson!

Well I did Marlene 15 years ago and that's in the style. It's somehow similar and not similar because Marlene was much more aggressive funny and sad.

It would be sad if my best work had been 20 years ago and now I only had memories.

I can't say I'm happy to be talking about John Ritter and his passing. In my 21 years of Entertainment Tonight this really was one of the most shocking and sad things to have happened.

Saturdays and Sundays America in the year 2009 does not in some ways differ significantly from the country that existed almost 50 years ago. This is truly sad.

Ideally I would love to mix singing and acting but you can only be a pop star for so many years. I mean at 30 it's a little bit sad right?

Home will always be Northern Ireland but my schedule means for the next few years I won't be there as much. I can't do the same things that I did a year ago. That is I'm something conscious of but I'm not sad about it. It's fine.

I have had stalkers over the years. The police deal with it but it is very scary. One man kept turning up where we filmed 'Countdown in Leeds ' which was scary. It was sad as he'd been sectioned and thought I was talking to him through the TV.

Wearing a tuxedo isn't as simple as it sounds. I've been to a lot of award shows in Hollywood over the years and have seen some pretty sad tuxes. It's surprisingly easy to go off the rails.

If I get the forty additional years statisticians say are likely coming to me I could fit in at least one maybe two new lifetimes. Sad that only one of those lifetimes can include being the mother of young children.

I've been on Prozac for 12 years and I'm off it now. I know what it feels like to be excited and sad again. I haven't felt like this in 12 years I'm like a giddy little kid.

Of these years nought remains in memory but the sad feeling that we have advanced and only grown older.

I enjoyed in every way my 12 years of playing Archie and I wasn't personally sad about finishing a long job.